Article
Chinese hamster cell mutant, V-C8, a model for analysis of Brca2 function.
Mutation research - 30 Aug 2006
Wiegant Wouter W, Overmeer René M, Godthelp Barbara C, van Buul Paul P W, Zdzienicka Małgorzata Z
Abstract excerpt
The previously described Chinese hamster cell mutant V-C8 that is defective in Brca2 shows a very complex phenotype, including increased sensitivity towards a wide variety of DNA damaging agents, chromosomal instability, abnormal centrosomes and impaired formation of Rad51 foci in response to DNA damage. Here, we demonstrate that V-C8 cells display biallelic nonsense mutations in Brca2, one in exon 15 and the...
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