Article
Mammalian Rad51C contributes to DNA cross-link resistance, sister chromatid cohesion and genomic stability.
Nucleic acids research - 15 May 2002
Godthelp Barbara C, Wiegant Wouter W, van Duijn-Goedhart Annemarie, Schärer Orlando D, van Buul Paul P W, Kanaar Roland, Zdzienicka Massgorzata Z
Abstract excerpt
The eukaryotic Rad51 protein is a structural and functional homolog of Escherichia coli RecA with a role in DNA repair and genetic recombination. Five paralogs of Rad51 have been identified in vertebrates, Rad51B, Rad51C, Rad51D, Xrcc2 and Xrcc3, which are also implicated in recombination and genome stability. Here, we identify a mammalian cell mutant in Rad51C. We show that the Chinese hamster cell mutant,...
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