Article
The Chinese hamster V79 cell mutant V-H4 is phenotypically like Fanconi anemia cells.
Somatic cell and molecular genetics - 1 Nov 1990
Zdzienicka M Z, Arwert F, Neuteboom I, Rooimans M, Simons J W
Abstract excerpt
It has been shown by genetic complementation analysis that a mitomycin C-sensitive mutant (V-H4) of Chinese hamster V79 cells is the first rodent equivalent of Fanconi anemia (FA) group A. The V-H4 mutant shows many typical characteristics of cells derived from FA patients. V-H4 cells exhibit inc...
Topics
- Alkylating Agents
- Animals
- Cell Line
- Cell Survival
- Chromosome Aberrations
- Cricetinae
- Cricetulus
- Cross-Linking Reagents
- DNA Damage
- DNA Repair
- Fanconi Anemia
- Genetic Complementation Test
- Humans
- Intercalating Agents
- Phenotype