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Article

Distinct cellular phenotype linked to defective DNA interstrand crosslink repair and homologous recombination.

Molecular medicine reports - 1 Aug 2017

Gorniewska Aleksandra M, Kluzek Katarzyna, Gackowska Lidia, Kubiszewska Izabela, Zdzienicka Malgorzata Z, Bialkowska Aneta

Abstract excerpt

Repair of DNA interstrand crosslinks (ICLs) predominantly involves the Fanconi anemia (FA) pathway and homologous recombination (HR). The HR repair system eliminates DNA double strand breaks (DSBs) that emerge during ICLs removal. The current study presents a novel cell line, CL‑V8B, representing a new complementation group of Chinese hamster cell mutants hypersensitive to DNA crosslinking factors. CL‑V8B...

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Identifiers

PMID: 28627616
DOI: 10.3892/mmr.2017.6781
PMCID: PMC5561886

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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