Article
Genetic diversity of mitomycin C-hypersensitive Chinese hamster cell mutants: a new complementation group with chromosomal instability.
Somatic cell and molecular genetics - 1 Sept 1993
Overkamp W J, Rooimans M A, Neuteboom I, Telleman P, Arwert F, Zdzienicka M Z
Abstract excerpt
A Chinese hamster cell mutant (V-C8) isolated previously, which is approximately 100 fold more sensitive to mitomycin C (MMC) than its parental wild-type V79 cells (judged by D10 values), was further characterized. V-C8 cells exhibit an increased sensitivity towards other cross-linking agents, su...
Topics
- Animals
- CHO Cells
- Cell Survival
- Chromosome Aberrations
- Cisplatin
- Cricetinae
- DNA Damage
- Dose-Response Relationship, Drug
- Doxorubicin
- Epoxy Compounds
- Genetic Complementation Test
- Genetic Variation
- Mitomycin
- Mutation