Article
Mutations in hamster single-strand break repair gene XRCC1 causing defective DNA repair.
Nucleic acids research - 15 Feb 1998
Shen M R, Zdzienicka M Z, Mohrenweiser H, Thompson L H, Thelen M P
Abstract excerpt
The molecular basis for the DNA repair dysfunction observed in mutant Chinese hamster ovary cell lines of X-ray repair cross complementing group 1 (XRCC1) is unknown and the exact role of the XRCC1 protein remains unclear. To help clarify the role of the XRCC1 gene we analyzed four mutant cell li...
Topics
- Alternative Splicing
- Amino Acid Sequence
- Animals
- Base Sequence
- CHO Cells
- Cricetinae
- DNA Primers
- DNA Repair
- DNA-Binding Proteins
- Genetic Complementation Test
- Humans
- Mice
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- RNA, Messenger
- Sequence Homology, Amino Acid
- X-ray Repair Cross Complementing Protein 1