Article
Brca2 (XRCC11) deficiency results in radioresistant DNA synthesis and a higher frequency of spontaneous deletions.
Molecular and cellular biology - 1 Jan 2002
Kraakman-van der Zwet Maria, Overkamp Wilhelmina J I, van Lange Rebecca E E, Essers Jeroen, van Duijn-Goedhart Annemarie, Wiggers Ingrid, Swaminathan Srividya, van Buul Paul P W, Errami Abdellatif, Tan Raoul T L, Jaspers Nicolaas G J, Sharan Shyam K, Kanaar Roland, Zdzienicka Malgorzata Z
Abstract excerpt
We show here that the radiosensitive Chinese hamster cell mutant (V-C8) of group XRCC11 is defective in the breast cancer susceptibility gene Brca2. The very complex phenotype of V-C8 cells is complemented by a single human chromosome 13 providing the BRCA2 gene, as well as by the murine Brca2 gene. The Brca2 deficiency in V-C8 cells causes hypersensitivity to various DNA-damaging agents with an extreme...
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