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Article

The Human Hypoxia-Inducible Factor 1α Gene:HIF1AStructure and Evolutionary Conservation

1 Sept 1998

Abstract excerpt

The HIF1A gene encodes the HIF-1alpha subunit of hypoxia-inducible factor 1, a transcription factor that is essential for cardiovascular development and systemic O2 homeostasis. HIF1A consists of 15 exons that are interrupted by introns at the same locations as in the mouse Hif1a gene, although sequences mediating alternative splicing and alternative translation initiation events in the mouse are not present in...

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PMID: 9782081
DOI: 10.1006/geno.1998.5416

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