Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The N-terminal transactivation domain confers target gene specificity of hypoxia-inducible factors HIF-1alpha and HIF-2alpha.

Molecular biology of the cell - 1 Nov 2007

Hu Cheng-Jun, Sataur Aneesa, Wang Liyi, Chen Hongqing, Simon M Celeste

Abstract excerpt

The basic helix-loop-helix-Per-ARNT-Sim-proteins hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha are the principal regulators of the hypoxic transcriptional response. Although highly related, they can activate distinct target genes. In this study, the protein domain and molecular mechanism important for HIF target gene specificity are determined. We demonstrate that although HIF-2alpha is unable to activate...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Basic Helix-Loop-Helix Transcription Factors
Share to Chromatin Immunoprecipitation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Embryonic Stem Cells

Share to Gene Expression Regulation

Share to Hypoxia-Inducible Factor 1, alpha Subunit

Share to Mice, Knockout

Share to Sensitivity and Specificity

Share to Transcriptional Activation

Source

Open in PubMed Open full text

Identifiers

PMID: 17804822
DOI: 10.1091/mbc.e06-05-0419
PMCID: PMC2043574

Genes

ARNT
EPO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The N-terminal transactivation domain confers target gene specificity of hypoxia-inducible factors HIF-1alpha and HIF-2alpha.PMID 17804822Read ↗

Differential regulation of the transcriptional activities of hypoxia-inducible factor 1 alpha (HIF-1alpha) and HIF-2alpha in stem cells.Semantic proximity Read ↗

Biology of hypoxia-inducible factor-2alpha in development and disease.Semantic proximity Read ↗

The hypoxia-inducible factor 2alpha N-terminal and C-terminal transactivation domains cooperate to promote renal tumorigenesis in vivo.Semantic proximity Read ↗

Hypoxia-inducible transcription factors: architects of tumorigenesis and targets for anticancer drug discoverySemantic proximity Read ↗

Hypoxia-inducible factors, hypoxia, and tumor angiogenesis.Semantic proximity Read ↗

Activation of C-transactivation domain is essential for optimal HIF-1 alpha-mediated transcriptional and angiogenic effects.Semantic proximity Read ↗

Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch.Semantic proximity Read ↗

The transcriptional factors HIF-1 and HIF-2 and their novel inhibitors in cancer therapySemantic proximity Read ↗

Differential Gene Up-Regulation by Hypoxia-Inducible Factor-1α and Hypoxia-Inducible Factor-2α in HEK293T CellsSemantic proximity Read ↗

Identification of Alternative Spliced Variants of Human Hypoxia-inducible Factor-1αSemantic proximity Read ↗

Functions of the Per/ARNT/Sim domains of the hypoxia-inducible factor.Semantic proximity Read ↗

Induction of Phosphoglycerate Kinase 1 Gene Expression by HypoxiaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.