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Article

Expression of hypoxia-inducible factor 1: mechanisms and consequences

1 Jan 2000

Abstract excerpt

Hypoxia-inducible factor 1 (HIF-1) is a basic-helix-loop-helix transcription factor that plays essential roles in mammalian development and physiology. HIF-1 is a heterodimer composed of HIF-1alpha and HIF-1beta subunits. The expression and activity of the HIF-1alpha subunit are tightly regulated by cellular O2 concentration. Under hypoxic conditions, HIF-1 activates the transcription of genes encoding...

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PMID: 10605934
DOI: 10.1016/s0006-2952(99)00292-0

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