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Article

Regulation of HIF prolyl hydroxylases by hypoxia-inducible factors.

Journal of cellular biochemistry - 1 Jun 2004

Aprelikova Olga, Chandramouli Gadisetti V R, Wood Matthew, Vasselli James R, Riss Joseph, Maranchie Jodi K, Linehan W Marston, Barrett J Carl

Abstract excerpt

Hypoxia and induction of hypoxia-inducible factors (HIF-1alpha and HIF-2alpha) is a hallmark of many tumors. Under normal oxygen tension HIF-alpha subunits are rapidly degraded through prolyl hydroxylase dependent interaction with the von Hippel-Lindau (VHL) tumor suppressor protein, a component of E3 ubuiquitin ligase complex. Using microarray analysis of VHL mutated and re-introduced cells, we found that one of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Dioxygenases

Share to Hypoxia-Inducible Factor 1, alpha Subunit

Share to Hypoxia-Inducible Factor-Proline Dioxygenases

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Source

Identifiers

PMID: 15156561
DOI: 10.1002/jcb.20067

Genes

VHL

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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