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Article

The transcriptional factors HIF-1 and HIF-2 and their novel inhibitors in cancer therapy

9 May 2019

Abstract excerpt

Introduction: Hypoxia is one of the intrinsic features of solid tumors, and it is always associated with aggressive phenotypes, including resistance to radiation and chemotherapy, metastasis, and poor patient prognosis. Hypoxia manifests these unfavorable effects through activation of a family of transcription factors, Hypoxia-inducible factors (HIFs) play a pivotal role in the adaptation of tumor cells to...

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PMID: 31070059
DOI: 10.1080/17460441.2019.1613370

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