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Article

HIF-2alpha regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth.

Genes & development - 1 Mar 2006

Covello Kelly L, Kehler James, Yu Hongwei, Gordan John D, Arsham Andrew M, Hu Cheng-Jun, Labosky Patricia A, Simon M Celeste, Keith Brian

Abstract excerpt

The division, differentiation, and function of stem cells and multipotent progenitors are influenced by complex signals in the microenvironment, including oxygen availability. Using a genetic "knock-in" strategy, we demonstrate that targeted replacement of the oxygen-regulated transcription factor HIF-1alpha with HIF-2alpha results in expanded expression of HIF-2alpha-specific target genes including Oct-4, a...

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Identifiers

PMID: 16510872
DOI: 10.1101/gad.1399906
PMCID: PMC1410808

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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HIF-2alpha regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth.PMID 16510872Read ↗

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