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Cancer stem cells and hypoxia-inducible factors (Review)

22 May 2018

Abstract excerpt

Cancer stem cells (CSCs), also known as tumor-initiating cells, are a subpopulation of tumor cells that exhibit properties similar to those of normal stem cells. Oxygen is an important regulator of cellular metabolism; hypoxia-inducible factors (HIFs) mediate metabolic switches in cells in hypoxic environments. Hypoxia clearly has the potential to exert a significant effect on the maintenance and evolution of...

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PMID: 29845228
DOI: 10.3892/ijo.2018.4417

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