Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Biology of hypoxia-inducible factor-2alpha in development and disease.

Cell death and differentiation - 1 Apr 2008

Patel S A, Simon M C

Abstract excerpt

The transcriptional response to hypoxia is primarily mediated by two hypoxia-inducible factors--HIF-1alpha and HIF-2alpha. While these proteins are highly homologous, increasing evidence suggests they have unique transcriptional targets and differential impact on tumor growth. Furthermore, non-transcriptional effects of the HIF-alpha subunits, including effects on the Notch and c-Myc pathways, contribute to their...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Basic Helix-Loop-Helix Transcription Factors
Share to Cell Hypoxia
Share to Cell Transformation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Hypoxia

Share to Mice, Knockout

Share to Neoplasms

Share to Tissue Distribution

Source

Open in PubMed Open full text

Identifiers

PMID: 18259197
DOI: 10.1038/cdd.2008.17
PMCID: PMC2882207

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Biology of hypoxia-inducible factor-2alpha in development and disease.PMID 18259197Read ↗

Hypoxia-inducible factors, hypoxia, and tumor angiogenesis.Semantic proximity Read ↗

Hypoxia-inducible factors: central regulators of the tumor phenotype.Semantic proximity Read ↗

Expression of hypoxia-inducible factor 1: mechanisms and consequencesSemantic proximity Read ↗

Differential regulation of the transcriptional activities of hypoxia-inducible factor 1 alpha (HIF-1alpha) and HIF-2alpha in stem cells.Semantic proximity Read ↗

Hypoxia inducible factor-2alpha: a critical mediator of aggressive tumor phenotypes.Semantic proximity Read ↗

Endothelial deletion of hypoxia-inducible factor-2alpha (HIF-2alpha) alters vascular function and tumor angiogenesis.Semantic proximity Read ↗

Mechanisms of adaptive angiogenesis to tissue hypoxia.Semantic proximity Read ↗

Hypoxia-inducible transcription factors: architects of tumorigenesis and targets for anticancer drug discoverySemantic proximity Read ↗

The transcriptional factors HIF-1 and HIF-2 and their novel inhibitors in cancer therapySemantic proximity Read ↗

Hypoxia and hypoxia-inducible factors in neuroblastomaSemantic proximity Read ↗

Hypoxia‐inducible factor 1 and cancer pathogenesisSemantic proximity Read ↗

Hypoxia-inducible factors: cancer progression and clinical translationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.