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Article

Identification of Alternative Spliced Variants of Human Hypoxia-inducible Factor-1α

1 Mar 2000

Abstract excerpt

Mammalian cells are able to sense oxygen and regulate a number of genes in response to hypoxia. The transcription factor Hypoxia Inducible Factor-1 (HIF-1) was identified as an important key component of the hypoxia signaling pathway. HIF-1 is a heterodimer composed of two members of the basic helix-loop-helix transcription factor superfamily containing a PAS (PER-ARNT-SIM) domain: HIF-1alpha and HIF-1beta/ARNT....

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PMID: 10702253
DOI: 10.1074/jbc.275.10.6922

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