Article
In vitro infection of immortalized primary hepatocytes by HCV genotype 4a and inhibition of virus replication by cyclosporin.
Microbiology and immunology - 1 Jan 2007
El-Farrash Mohamed A, Aly Hussein H, Watashi Koichi, Hijikata Makoto, Egawa Hiroto, Shimotohno Kunitada
Abstract excerpt
Hepatitis C virus (HCV) is a major cause of liver cirrhosis and hepatocellular carcinoma worldwide. We previously reported that cyclosporin A (CsA) inhibits HCV-1b replication. However, its inhibition of JFH-1 (HCV-2a) was much less. Since HCV genotype clearly affects the in vitro and in vivo response to anti-viral therapy, we wished to examine the effect of CsA and its non-immunosuppressive derivative NIM811 on...
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