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Article

Essential role of cyclophilin A for hepatitis C virus replication and virus production and possible link to polyprotein cleavage kinetics.

PLoS pathogens - 1 Aug 2009

Kaul Artur, Stauffer Sarah, Berger Carola, Pertel Thomas, Schmitt Jennifer, Kallis Stephanie, Zayas Margarita, Lopez Margarita Zayas, Lohmann Volker, Luban Jeremy, Bartenschlager Ralf

Abstract excerpt

Viruses are obligate intracellular parasites and therefore their replication completely depends on host cell factors. In case of the hepatitis C virus (HCV), a positive-strand RNA virus that in the majority of infections establishes persistence, cyclophilins are considered to play an important role in RNA replication. Subsequent to the observation that cyclosporines, known to sequester cyclophilins by direct...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19680534
DOI: 10.1371/journal.ppat.1000546
PMCID: PMC2718831

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Essential role of cyclophilin A for hepatitis C virus replication and virus production and possible link to polyprotein cleavage kinetics.PMID 19680534Read ↗

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