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Article

Cyclosporin A inhibits the replication of diverse coronaviruses

14 Jul 2011

Abstract excerpt

Low micromolar, non-cytotoxic concentrations of cyclosporin A (CsA) strongly affected the replication of severe acute respiratory syndrome coronavirus (SARS-CoV), human coronavirus 229E and mouse hepatitis virus in cell culture, as was evident from the strong inhibition of GFP reporter gene expression and a reduction of up to 4 logs in progeny titres. Upon high-multiplicity infection, CsA treatment rendered...

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PMID: 21752960
DOI: 10.1099/vir.0.034983-0

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Cyclosporin A inhibits the replication of diverse coronavirusesPMID 21752960Read ↗

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