Article
Genotoxicity of glycidamide in comparison to (+/-)-anti-benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide and alpha-acetoxy-N-nitroso-diethanolamine in human blood and in mammalian V79-cells.
Molecular nutrition & food research - 1 Apr 2006
Thielen Silke, Baum Matthias, Hoffmann Michelle, Loeppky Richard N, Eisenbrand Gerhard
Abstract excerpt
Genotoxic activity of glycidamide (GA) was investigated in comparison to that of the known carcinogens (+/-)-anti-benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide ((+/-)-BPDE) and alpha-acetoxy-N-nitroso-diethanolamine (alpha-A-NDELA), using the hypoxanthine-phosphoribosyl-transferase (hPRT) gene muta...
Topics
- 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
- Animals
- Cell Line
- Cricetinae
- Cricetulus
- DNA
- DNA Damage
- Diethylnitrosamine
- Epoxy Compounds
- Fibroblasts
- Hypoxanthine Phosphoribosyltransferase
- Lung
- Lymphocytes
- Mutagens
- Mutation