Article
Genotoxicity of glycidamide in comparison to 3-N-nitroso-oxazolidin-2-one.
Journal of agricultural and food chemistry - 13 Aug 2008
Baum Matthias, Loeppky Richard N, Thielen Silke, Eisenbrand Gerhard
Abstract excerpt
Acrylamide (AA) is generated by thermal processing of foods, depending on processing conditions and precursor availability. AA is not genotoxic by itself but becomes activated to its genotoxic metabolite glycidamide (GA) via epoxidation, mediated primarily by cytochrome P450 2E1. In the Comet ass...
Topics
- Animals
- Cell Line
- Cricetinae
- Cricetulus
- DNA Damage
- DNA Repair
- Epoxy Compounds
- Hypoxanthine Phosphoribosyltransferase
- Lung
- Mutagens
- Mutation
- Nitrosamines
- Oxazolidinones