Article
Genetic polymorphisms in detoxification and DNA repair genes and susceptibility to glycidamide-induced DNA damage.
Journal of toxicology and environmental health. Part A - 1 Jan 2012
Pingarilho Marta, Oliveira Nuno G, Martins Célia, Fernandes Ana Sofia, de Lima João Pereira, Rueff José, Gaspar Jorge Francisco
Abstract excerpt
Acrylamide (AA) is a probable human carcinogen formed in carbohydrate-rich foodstuffs upon heating. Glycidamide (GA), the AA metabolite formed by epoxidation, is considered the ultimate genotoxic agent. In this study, the in vitro genotoxic potential of AA and GA in human whole blood leukocytes w...
Topics
- Acrylamide
- Adult
- Amino Acid Substitution
- Carcinogens, Environmental
- DNA Damage
- DNA Glycosylases
- DNA Repair
- DNA-Binding Proteins
- Epoxy Compounds
- Female
- Genetic Association Studies
- Humans
- Leukocytes
- Male
- Mutagens
- Osmolar Concentration
- Polymorphism, Single Nucleotide
- Portugal