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Article

Genotoxicity of acrylamide and glycidamide in human lymphoblastoid TK6 cells.

Mutation research - 28 Feb 2006

Koyama Naoki, Sakamoto Hiroko, Sakuraba Mayumi, Koizumi Tomoko, Takashima Yoshio, Hayashi Makoto, Matsufuji Hiroshi, Yamagata Kazuo, Masuda Shuichi, Kinae Naohide, Honma Masamitsu

Abstract excerpt

The recent finding that acrylamide (AA), a potent carcinogen, is formed in foods during cooking raises human health concerns. In the present study, we investigated the genotoxicity of AA and its metabolite glycidamide (GA) in human lymphoblastoid TK6 cells examining three endpoints: DNA damage (comet assay), clastogenesis (micronucleus test) and gene mutation (thymidine kinase (TK) assay). In a 4 h treatment...

Topics

Acrylamide
Animals
Comet Assay
DNA Damage
Epoxy Compounds
Humans
Liver
Loss of Heterozygosity
Lymphocytes
Micronucleus Tests
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Rats

Thymidine Kinase

Source

Identifiers

PMID: 16387526
DOI: 10.1016/j.mrgentox.2005.11.006

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-16387526-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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