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Article

A common microdeletion affecting a hippocampus- and amygdala-specific isoform of tryptophan hydroxylase 2 is not associated with affective disorders.

Bipolar disorders - 1 Nov 2014

Hammer Christian, Degenhardt Franziska, Priebe Lutz, Stütz Adrian M, Heilmann Stefanie, Waszak Sebastian M, Schlattl Andreas, Mangold Elisabeth, Hoffmann Per, Nöthen Markus M, Rietschel Marcella, Rappold Gudrun, Korbel Jan, Cichon Sven, Niesler Beate

Abstract excerpt

OBJECTIVES: Copy number variants (CNVs) have been shown to affect susceptibility for neuropsychiatric disorders. To date, studies implicating the serotonergic system in complex conditions have just focused on single nucleotide polymorphisms (SNPs). We therefore sought to identify novel common genetic copy number polymorphisms affecting genes of the serotonergic system, and to assess their putative role in bipolar...

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Identifiers

PMID: 24754353
DOI: 10.1111/bdi.12207

Genes

TPH2

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A common microdeletion affecting a hippocampus- and amygdala-specific isoform of tryptophan hydroxylase 2 is not associated with affective disorders.PMID 24754353Read ↗

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SNP and haplotype analysis of a novel tryptophan hydroxylase isoform (TPH2) gene provide evidence for association with major depression.Semantic proximity Read ↗

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