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Article

The dual structural roles of the membrane distal region of the α-integrin cytoplasmic tail during integrin inside-out activation.

Journal of cell science - 1 May 2015

Liu Jiafu, Wang Zhengli, Thinn Aye Myat Myat, Ma Yan-Qing, Zhu Jieqing

Abstract excerpt

Studies on the mechanism of integrin inside-out activation have been focused on the role of β-integrin cytoplasmic tails, which are relatively conserved and bear binding sites for the intracellular activators including talin and kindlin. Cytoplasmic tails for α-integrins share a conserved GFFKR m...

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Identifiers

PMID: 25749862
DOI: 10.1242/jcs.160663
PMCID: PMC6518327

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25749862-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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