Article
Nascent Integrin Adhesions Form on All Matrix Rigidities after Integrin Activation.
Developmental cell - 7 Dec 2015
Changede Rishita, Xu Xiaochun, Margadant Felix, Sheetz Michael P
Abstract excerpt
Integrin adhesions assemble and mature in response to ligand binding and mechanical factors, but the molecular-level organization is not known. We report that ∼100-nm clusters of ∼50 β3-activated integrins form very early adhesions under a wide variety of conditions on RGD surfaces. These adhesions form similarly on fluid and rigid substrates, but most adhesions are transient on rigid substrates. Without talin or...
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