Article
Talin regulates integrin β1-dependent and -independent cell functions in ureteric bud development.
Development (Cambridge, England) - 15 Nov 2017
Mathew Sijo, Palamuttam Riya J, Mernaugh Glenda, Ramalingam Harini, Lu Zhenwei, Zhang Ming-Zhi, Ishibe Shuta, Critchley David R, Fässler Reinhard, Pozzi Ambra, Sanders Charles R, Carroll Thomas J, Zent Roy
Abstract excerpt
Kidney collecting system development requires integrin-dependent cell-extracellular matrix interactions. Integrins are heterodimeric transmembrane receptors consisting of α and β subunits; crucial integrins in the kidney collecting system express the β1 subunit. The β1 cytoplasmic tail has two NPxY motifs that mediate functions by binding to cytoplasmic signaling and scaffolding molecules. Talins, scaffolding...
Topics
- Adherens Junctions
- Amino Acid Motifs
- Animals
- Binding Sites
- Cell Adhesion
- Cell Membrane
- Cell Polarity
- Gene Expression Regulation, Developmental
- Integrin beta1
- Kidney Tubules, Collecting