Article
Multiscale simulations suggest a mechanism for integrin inside-out activation.
Proceedings of the National Academy of Sciences of the United States of America - 19 Jul 2011
Kalli Antreas C, Campbell Iain D, Sansom Mark S P
Abstract excerpt
Integrins are large cell-surface adhesion receptors that can be activated to a high affinity state by the formation of an intracellular complex between the integrin β-subunit tail, the membrane, and talin. The F2 and F3 subdomains of the talin head play a key role in formation of this complex. Here, activation of the integrin αIIb/β3 dimer by the talin head domain was probed using multiscale molecular dynamics...
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