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Article

Islet recovery and reversal of murine type 1 diabetes in the absence of any infused spleen cell contribution.

Science (New York, N.Y.) - 24 Mar 2006

Nishio Junko, Gaglia Jason L, Turvey Stuart E, Campbell Christopher, Benoist Christophe, Mathis Diane

Abstract excerpt

A cure for type 1 diabetes will probably require the provision or elicitation of new pancreatic islet beta cells as well as the reestablishment of immunological tolerance. A 2003 study reported achievement of both advances in the NOD mouse model by coupling injection of Freund's complete adjuvant with infusion of allogeneic spleen cells. It was concluded that the adjuvant eliminated anti-islet autoimmunity and...

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Identifiers

PMID: 16556845
DOI: 10.1126/science.1124004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Islet recovery and reversal of murine type 1 diabetes in the absence of any infused spleen cell contribution.PMID 16556845Read ↗

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