Article
Selective depletion of alloreactive T cells leads to long-term islet allograft survival across a major histocompatibility complex mismatch in diabetic mice.
Cell transplantation - 1 Jan 2013
Hu M, Wu J, Zhang G Y, Wang Y M, Watson D, Yi S, Hawthorne W J, O'Connell P J, Alexander S I
Abstract excerpt
Islet cell transplantation as a therapy for type 1 diabetes has been limited by progressive graft loss. Significant immunosuppression including T-cell ablation has been used in an attempt to limit islet rejection. Here, we show that CD3(+) lymphocytes depleted of alloreactive T cells selected from a mixed lymphocyte reaction (MLR), where responder BALB/c splenocytes stained with carboxyfluorescein succinimidyl...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.