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Article

Evidence for direct and indirect pathways in the generation of the alloimmune response against pancreatic islets.

Transplantation - 1 Oct 1991

Stock P G, Ascher N L, Chen S, Field J, Bach F H, Sutherland D E

Abstract excerpt

The role of the direct and indirect pathways of alloantigen presentation in the generation of the alloimmune response was dissected using the murine mixed lymphocyte-islet coculture system (MLIC). Stimulator DBA/2J (H-2d) pancreatic islet populations consisted of whole islets (MHC class I+, II+) or FACS-purified beta cells (MHC class I+, II-). Responding C57Bl/6 (H-2b) splenocyte populations were either: (1)...

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PMID: 1833868
DOI: 10.1097/00007890-199110000-00023

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APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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