Article
Evidence for direct and indirect pathways in the generation of the alloimmune response against pancreatic islets.
Transplantation - 1 Oct 1991
Stock P G, Ascher N L, Chen S, Field J, Bach F H, Sutherland D E
Abstract excerpt
The role of the direct and indirect pathways of alloantigen presentation in the generation of the alloimmune response was dissected using the murine mixed lymphocyte-islet coculture system (MLIC). Stimulator DBA/2J (H-2d) pancreatic islet populations consisted of whole islets (MHC class I+, II+) or FACS-purified beta cells (MHC class I+, II-). Responding C57Bl/6 (H-2b) splenocyte populations were either: (1)...
Topics
- Animals
- Antigen-Presenting Cells
- Histocompatibility Antigens Class II
- Islets of Langerhans
- Isoantibodies
- Isoantigens
- Lymphocyte Activation
- Lymphocyte Culture Test, Mixed
- Lymphocyte Subsets
- Mice
- Mice, Inbred C57BL