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Article

Prevention of insulitis and diabetes onset by treatment with complete Freund's adjuvant in NOD mice.

Diabetes - 1 Jun 1991

McInerney M F, Pek S B, Thomas D W

Abstract excerpt

In studies of immune cell defects in autoimmune diabetes mellitus, we observed that complete Freund's adjuvant (CFA) prevented the onset of diabetes when injected into 8- to 10-wk-old prediabetic nonobese diabetic (NOD) mice. The prevalence of the onset of diabetes in the CFA-injected versus uninjected NOD mice was 2 of 81 (2.5%) vs. 231 of 379 (61%) among females and 2 of 44 (4.5%) vs. 83 of 336 (25%) among...

Topics

Animals
Cells, Cultured
Concanavalin A
Diabetes Mellitus, Experimental
Freund's Adjuvant
Islets of Langerhans
Lymphocyte Activation
Mice
Mice, Mutant Strains
Pancreatic Diseases
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Prediabetic State

Spleen

T-Lymphocytes

Source

Identifiers

PMID: 2040388
DOI: 10.2337/diab.40.6.715

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2040388-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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