Inclusion of peripancreatic lymph node cells prevents recurrent autoimmune destruction of islet transplants: evidence of donor chimerism.

doi:10.1016/s0039-6060(05)80350-2

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Article

Inclusion of peripancreatic lymph node cells prevents recurrent autoimmune destruction of islet transplants: evidence of donor chimerism.

Surgery - 1 Aug 1995

Bartlett S T, Chin T, Dirden B, Quereshi A, Hadley G

Abstract excerpt

BACKGROUND: Recurrent autoimmune beta-cell destruction may contribute to the poor results of clinical islet transplantation. Pancreas transplants from diabetes-resistant BB rats (BB-DR) are uniformly successful in autoimmune diabetic BB rats (BB-Ac), but isolated islets are destroyed, despite immunosuppression. In this study we tested the hypothesis that whole pancreas transplants abrogate autoimmunity by passive...

Topics

Animals
Autoimmune Diseases
Cell Transplantation
Chimera
Diabetes Mellitus
Genetic Predisposition to Disease
Islets of Langerhans Transplantation
Lymph Nodes
Pancreas
Pancreas Transplantation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Rats

Rats, Inbred BB

Rats, Inbred WF

Recurrence

T-Lymphocytes

Tissue Donors

Source

Open in PubMed

Identifiers

PMID: 7638756
DOI: 10.1016/s0039-6060(05)80350-2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7638756-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Inclusion of peripancreatic lymph node cells prevents recurrent autoimmune destruction of islet transplants: evidence of donor chimerism.PMID 7638756Read ↗

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