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Article

Inclusion of peripancreatic lymph node cells prevents recurrent autoimmune destruction of islet transplants: evidence of donor chimerism.

Surgery - 1 Aug 1995

Bartlett S T, Chin T, Dirden B, Quereshi A, Hadley G

Abstract excerpt

BACKGROUND: Recurrent autoimmune beta-cell destruction may contribute to the poor results of clinical islet transplantation. Pancreas transplants from diabetes-resistant BB rats (BB-DR) are uniformly successful in autoimmune diabetic BB rats (BB-Ac), but isolated islets are destroyed, despite immunosuppression. In this study we tested the hypothesis that whole pancreas transplants abrogate autoimmunity by passive...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 7638756
DOI: 10.1016/s0039-6060(05)80350-2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inclusion of peripancreatic lymph node cells prevents recurrent autoimmune destruction of islet transplants: evidence of donor chimerism.PMID 7638756Read ↗

Selective depletion of alloreactive T cells leads to long-term islet allograft survival across a major histocompatibility complex mismatch in diabetic mice.Semantic proximity Read ↗

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CD8+ T-cells are required for adoptive transfer of the BB rat diabetic syndrome.Semantic proximity Read ↗

Donor B Cells in Transplants Augment Clonal Expansion and Survival of Pathogenic CD4+ T Cells That Mediate Autoimmune-like Chronic Graft-versus-Host DiseaseSemantic proximity Read ↗

Ontogeny and immunohistochemical localization of thymus-dependent and thymus-independent RT6+ cells in the rat.Semantic proximity Read ↗

Donor-derived CD8 <sup>+</sup> CD122 <sup>+</sup> Tregs generated in mixed donor chimeric NOD mice delete autoreactive T cellsSemantic proximity Read ↗

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T-lymphocyte requirement for diabetes in RT6-depleted diabetes-resistant BB rats.Semantic proximity Read ↗

Antigen-Encoding Bone Marrow Terminates Islet-Directed Memory CD8+ T-Cell Responses to Alleviate Islet Transplant RejectionSemantic proximity Read ↗

Specific destruction of islet transplants in NOD<-->C57BL/6 and NOD<-->C3H/Tif embryo aggregation chimeras irrespective of allelic differences in beta-cell antigens.Semantic proximity Read ↗

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