Article
Mixed allogeneic chimerism induced by a sublethal approach prevents autoimmune diabetes and reverses insulitis in nonobese diabetic (NOD) mice.
Journal of immunology (Baltimore, Md. : 1950) - 1 Jan 1996
Li H, Kaufman C L, Boggs S S, Johnson P C, Patrene K D, Ildstad S T
Abstract excerpt
Evidence in experimental models suggests that many autoimmune diseases can be prevented by transplantation of bone marrow from disease-resistant donors. For potential clinical application, it would be important to avoid the morbidity and mortality associated with lethal conditioning and achieve mixed chimerism using less than complete recipient ablation. We report here for the first time that stable chimerism...
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