Article
The intrinsic ATPase activity of Mycobacterium tuberculosis DnaA promotes rapid oligomerization of DnaA on oriC.
Molecular microbiology - 1 Mar 2006
Madiraju Murty V V S, Moomey Meredith, Neuenschwander Pierre F, Muniruzzaman Syed, Yamamoto Kohji, Grimwade Julia E, Rajagopalan Malini
Abstract excerpt
Oligomerization of the initiator protein, DnaA, on the origin of replication (oriC) is crucial for initiation of DNA replication. Studies in Escherichia coli (Gram-negative) have revealed that binding of DnaA to ATP, but not hydrolysis of ATP, is sufficient to promote DnaA binding, oligomerization and DNA strand separation. To begin understanding the initial events involved in the initiation of DNA replication in...
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