Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutations in the CCGTTCACA DnaA box of Mycobacterium tuberculosis oriC that abolish replication of oriC plasmids are tolerated on the chromosome.

Journal of bacteriology - 1 Jul 2002

Dziadek Jaroslaw, Rajagopalan Malini, Parish Tanya, Kurepina Natalia, Greendyke Rebecca, Kreiswirth Barry N, Madiraju Murty V V S

Abstract excerpt

The origin of replication (oriC) region in some clinical strains of Mycobacterium tuberculosis is a hot spot for IS6110 elements. To understand how clinical strains with insertions in oriC can replicate their DNA, we characterized the oriC regions of some clinical strains. Using a plasmid-based oriC-dependent replication assay, we showed that IS6110 insertions that disrupted the DnaA box sequence CCGTTCACA...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bacterial Proteins
Share to Base Sequence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Bacterial

Share to DNA-Binding Proteins

Share to DNA Transposable Elements

Share to Mycobacterium tuberculosis

Share to Plasmids

Share to Replication Origin

Source

Open in PubMed Open full text

Identifiers

PMID: 12081955
DOI: 10.1128/JB.184.14.3848-3855.2002
PMCID: PMC135179

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutations in the CCGTTCACA DnaA box of Mycobacterium tuberculosis oriC that abolish replication of oriC plasmids are tolerated on the chromosome.PMID 12081955Read ↗

Replacement of Mycobacterium smegmatis dnaA gene by Mycobacterium tuberculosis homolog results in temperature sensitivity.Semantic proximity Read ↗

Mycobacterium tuberculosis Origin of Replication and the Promoter for Immunodominant Secreted Antigen 85B Are the Targets of MtrA, the Essential Response RegulatorSemantic proximity Read ↗

The intrinsic ATPase activity of Mycobacterium tuberculosis DnaA promotes rapid oligomerization of DnaA on oriC.Semantic proximity Read ↗

IS6110 in oriC affects the morphology and growth of Mycobacterium tuberculosis and attenuates virulence in mice.Semantic proximity Read ↗

Structural and thermodynamic signatures of DNA recognition by Mycobacterium tuberculosis DnaA.Semantic proximity Read ↗

The DnaA box R4 in the minimal oriC is dispensable for initiation of Escherichia coli chromosome replication.Semantic proximity Read ↗

Identification of oriT and a recombination hot spot in the IncA/C plasmid backbone.Semantic proximity Read ↗

Synchronous replication initiation in novel Mycobacterium tuberculosis dnaA cold-sensitive mutants.Semantic proximity Read ↗

The sequence requirements for a functional Escherichia coli replication origin are different for the chromosome and a minichromosome.Semantic proximity Read ↗

A common mechanism for the ATP-DnaA-dependent formation of open complexes at the replication origin.Semantic proximity Read ↗

Molecular characterization of the eis promoter of Mycobacterium tuberculosis.Semantic proximity Read ↗

A comprehensive set of DnaA-box mutations in the replication origin, oriC, of Escherichia coli.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.