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Article

Synchronous replication initiation in novel Mycobacterium tuberculosis dnaA cold-sensitive mutants.

Molecular microbiology - 1 Jan 2009

Nair Naveen, Dziedzic Renata, Greendyke Rebecca, Muniruzzaman Syed, Rajagopalan Malini, Madiraju Murty V

Abstract excerpt

The genetic aspects of oriC replication initiation in Mycobacterium tuberculosis are largely unknown. A two-step genetic screen was utilized for isolating M. tuberculosis dnaA cold-sensitive (cos) mutants. First, a resident plasmid expressing functional dnaA integrated at the attB locus in dnaA null background was exchanged with an incoming plasmid bearing a mutagenized dnaA gene. Next, the mutants that were...

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Identifiers

PMID: 19019143
DOI: 10.1111/j.1365-2958.2008.06523.x
PMCID: PMC2733369

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Source receipt: pubmed, retrieved 7 Sept 2026.

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