Article
Brat is a Miranda cargo protein that promotes neuronal differentiation and inhibits neuroblast self-renewal.
Developmental cell - 1 Apr 2006
Lee Cheng-Yu, Wilkinson Brian D, Siegrist Sarah E, Wharton Robin P, Doe Chris Q
Abstract excerpt
An important question in stem cell biology is how a cell decides to self-renew or differentiate. Drosophila neuroblasts divide asymmetrically to self-renew and generate differentiating progeny called GMCs. Here, we report that the Brain tumor (Brat) translation repressor is partitioned into GMCs via direct interaction with the Miranda scaffolding protein. In brat mutants, another Miranda cargo protein (Prospero)...
Topics
- Animals
- Cell Count
- Cell Cycle Proteins
- Cell Differentiation
- Cells, Cultured
- DNA-Binding Proteins
- Drosophila Proteins
- Drosophila melanogaster
- Gene Expression Regulation
- Mutation
- Nerve Tissue Proteins
- Neurons
- Nuclear Proteins
- Protein Transport
- Stem Cells
- Transcription Factors