Article
Prospero acts as a binary switch between self-renewal and differentiation in Drosophila neural stem cells.
Developmental cell - 1 Dec 2006
Choksi Semil P, Southall Tony D, Bossing Torsten, Edoff Karin, de Wit Elzo, Fischer Bettina E, van Steensel Bas, Micklem Gos, Brand Andrea H
Abstract excerpt
Stem cells have the remarkable ability to give rise to both self-renewing and differentiating daughter cells. Drosophila neural stem cells segregate cell-fate determinants from the self-renewing cell to the differentiating daughter at each division. Here, we show that one such determinant, the homeodomain transcription factor Prospero, regulates the choice between stem cell self-renewal and differentiation. We...
Topics
- Animals
- Animals, Genetically Modified
- Biomarkers
- Cell Differentiation
- Cell Proliferation
- Drosophila Proteins
- Drosophila melanogaster
- Gene Expression Profiling
- Genome
- Mutation
- Nerve Tissue Proteins
- Neurons
- Nuclear Proteins