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Article

Miranda as a multidomain adapter linking apically localized Inscuteable and basally localized Staufen and Prospero during asymmetric cell division in Drosophila.

Genes & development - 15 Jun 1998

Shen C P, Knoblich J A, Chan Y M, Jiang M M, Jan L Y, Jan Y N

Abstract excerpt

Neuroblasts in the developing Drosophila CNS asymmetrically localize the cell fate determinants Numb and Prospero as well as prospero RNA to the basal cortex during mitosis. The localization of Prospero requires the function of inscuteable and miranda, whereas prospero RNA localization requires inscuteable and staufen function. We demonstrate that Miranda contains multiple functional domains: an amino-terminal...

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Identifiers

PMID: 9637685
DOI: 10.1101/gad.12.12.1837
PMCID: PMC316910

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Research trail→

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Miranda as a multidomain adapter linking apically localized Inscuteable and basally localized Staufen and Prospero during asymmetric cell division in Drosophila.PMID 9637685Read ↗

Identification of Miranda protein domains regulating asymmetric cortical localization, cargo binding, and cortical release.Semantic proximity Read ↗

miranda localizes staufen and prospero asymmetrically in mitotic neuroblasts and epithelial cells in early Drosophila embryogenesis.Semantic proximity Read ↗

Miranda directs Prospero to a daughter cell during Drosophila asymmetric divisions.Semantic proximity Read ↗

Bazooka recruits Inscuteable to orient asymmetric cell divisions in Drosophila neuroblasts.Semantic proximity Read ↗

Role of inscuteable in orienting asymmetric cell divisions in Drosophila.Semantic proximity Read ↗

Bazooka provides an apical cue for Inscuteable localization in Drosophila neuroblasts.Semantic proximity Read ↗

Miranda couples oskar mRNA/Staufen complexes to the bicoid mRNA localization pathway.Semantic proximity Read ↗

cdc2 links the Drosophila cell cycle and asymmetric division machineries.Semantic proximity Read ↗

Asymmetric segregation of the tumor suppressor brat regulates self-renewal in Drosophila neural stem cells.Semantic proximity Read ↗

Brat is a Miranda cargo protein that promotes neuronal differentiation and inhibits neuroblast self-renewal.Semantic proximity Read ↗

Role of cortical tumour-suppressor proteins in asymmetric division of Drosophila neuroblast.Semantic proximity Read ↗

Protein phosphatase 4 mediates localization of the Miranda complex during Drosophila neuroblast asymmetric divisions.Semantic proximity Read ↗

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