Article
Miranda as a multidomain adapter linking apically localized Inscuteable and basally localized Staufen and Prospero during asymmetric cell division in Drosophila.
Genes & development - 15 Jun 1998
Shen C P, Knoblich J A, Chan Y M, Jiang M M, Jan L Y, Jan Y N
Abstract excerpt
Neuroblasts in the developing Drosophila CNS asymmetrically localize the cell fate determinants Numb and Prospero as well as prospero RNA to the basal cortex during mitosis. The localization of Prospero requires the function of inscuteable and miranda, whereas prospero RNA localization requires i...
Topics
- Actins
- Animals
- Binding Sites
- Cell Cycle Proteins
- Cell Division
- Central Nervous System
- Cytoskeletal Proteins
- Drosophila
- Drosophila Proteins
- Gene Expression
- Insect Proteins
- Juvenile Hormones
- Male
- Mitosis
- Mutation