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Article

Miranda directs Prospero to a daughter cell during Drosophila asymmetric divisions.

Nature - 11 Dec 1997

Ikeshima-Kataoka H, Skeath J B, Nabeshima Y, Doe C Q, Matsuzaki F

Abstract excerpt

Asymmetric cell division is a general process used in many developmental contexts to create two differently fated cells from a single progenitor cell. Intrinsic mechanisms like the asymmetric transmission of cell-fate determinants during cell division, and extrinsic cell-interaction mechanisms, can mediate asymmetric divisions. During embryonic development of the Drosophila central nervous system, neural stem...

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PMID: 9403694
DOI: 10.1038/37641

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Miranda directs Prospero to a daughter cell during Drosophila asymmetric divisions.PMID 9403694Read ↗

miranda localizes staufen and prospero asymmetrically in mitotic neuroblasts and epithelial cells in early Drosophila embryogenesis.Semantic proximity Read ↗

Identification of Miranda protein domains regulating asymmetric cortical localization, cargo binding, and cortical release.Semantic proximity Read ↗

Miranda as a multidomain adapter linking apically localized Inscuteable and basally localized Staufen and Prospero during asymmetric cell division in Drosophila.Semantic proximity Read ↗

Progenitor properties of symmetrically dividing Drosophila neuroblasts during embryonic and larval development.Semantic proximity Read ↗

Asymmetric segregation of the tumor suppressor brat regulates self-renewal in Drosophila neural stem cells.Semantic proximity Read ↗

Prospero acts as a binary switch between self-renewal and differentiation in Drosophila neural stem cells.Semantic proximity Read ↗

A mosaic genetic screen for novel mutations affecting Drosophila neuroblast divisions.Semantic proximity Read ↗

Slit signaling promotes the terminal asymmetric division of neural precursor cells in the Drosophila CNS.Semantic proximity Read ↗

Pan-neural Prospero terminates cell proliferation during Drosophila neurogenesis.Semantic proximity Read ↗

Brat is a Miranda cargo protein that promotes neuronal differentiation and inhibits neuroblast self-renewal.Semantic proximity Read ↗

The prospero gene specifies cell fates in the Drosophila central nervous system.Semantic proximity Read ↗

Jumeaux, a novel Drosophila winged-helix family protein, is required for generating asymmetric sibling neuronal cell fates.Semantic proximity Read ↗

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