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Article

Brat promotes stem cell differentiation via control of a bistable switch that restricts BMP signaling.

Developmental cell - 18 Jan 2011

Harris Robin E, Pargett Michael, Sutcliffe Catherine, Umulis David, Ashe Hilary L

Abstract excerpt

Drosophila ovarian germline stem cells (GSCs) are maintained by Dpp signaling and the Pumilio (Pum) and Nanos (Nos) translational repressors. Upon division, Dpp signaling is extinguished, and Nos is downregulated in one daughter cell, causing it to switch to a differentiating cystoblast (CB). However, downstream effectors of Pum-Nos remain unknown, and how CBs lose their responsiveness to Dpp is unclear. Here, we...

Topics

Animals
Bone Morphogenetic Proteins
Cell Count
Cell Differentiation
Cell Proliferation
DNA-Binding Proteins
Drosophila Proteins
Drosophila melanogaster
Female
Models, Biological
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Ovary

Protein Binding

Repressor Proteins

Signal Transduction

Stem Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 21238926
DOI: 10.1016/j.devcel.2010.11.019
PMCID: PMC3178012

Genes

GSC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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