Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The RNA-binding activity of the Drosophila Brat protein is necessary for viability and mRNA regulation.

RNA biology - 1 Dec 2026

Connacher Robert P, Hu Yichao, Roden Richard, Toledo Julia, DesMarais Anna, O'Connor Michael, Lipshitz Howard D, Goldstrohm Aaron C

Abstract excerpt

Brain tumor (Brat) is a Drosophila TRIM-NHL protein required for embryogenesis and neural stem cell differentiation. Although structural and biochemical studies established that the Brat NHL domain specifically binds RNA, the in vivo requirement for this activity has not been directly tested. Here, we used structure-guided mutagenesis and genome engineering to determine whether RNA recognition is essential for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Binding Sites
Share to DNA-Binding Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drosophila melanogaster

Share to Drosophila Proteins

Share to Gene Expression Regulation, Developmental

Share to Protein Binding

Share to RNA-Binding Proteins

Share to RNA, Messenger

Source

Open in PubMed Open full text

Identifiers

PMID: 42206510
DOI: 10.1080/15476286.2026.2682069
PMCID: PMC13245067

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The RNA-binding activity of the Drosophila Brat protein is necessary for viability and mRNA regulation.PMID 42206510Read ↗

The NHL domain of BRAT is an RNA-binding domain that directly contacts the hunchback mRNA for regulation.Semantic proximity Read ↗

Brain tumor is a sequence-specific RNA-binding protein that directs maternal mRNA clearance during the Drosophila maternal-to-zygotic transition.Semantic proximity Read ↗

Drosophila Brain Tumor is a translational repressor.Semantic proximity Read ↗

A Novel Mutation in Brain Tumor Causes Both Neural Over-Proliferation and Neurodegeneration in Adult Drosophila.Semantic proximity Read ↗

The RNA binding protein Nab2 regulates splicing of the RhoGEF <i>trio</i> transcript to govern axon and dendrite morphologySemantic proximity Read ↗

The Nab2 RNA binding protein promotes sex-specific splicing of <i>Sex lethal</i> in <i>Drosophila</i> neuronal tissueSemantic proximity Read ↗

Antagonistic roles of Drosophila Tctp and Brahma in chromatin remodelling and stabilizing repeated sequencesSemantic proximity Read ↗

The TRIM-NHL protein NHL-2 is a Novel Co-Factor of the CSR-1 and HRDE-1 22G-RNA PathwaysSemantic proximity Read ↗

Brat is a Miranda cargo protein that promotes neuronal differentiation and inhibits neuroblast self-renewal.Semantic proximity Read ↗

BRAT1 links Integrator and defective RNA processing with neurodegeneration.Semantic proximity Read ↗

LINT, a novel dL(3)mbt-containing complex, represses malignant brain tumour signature genes.Semantic proximity Read ↗

Genetic analysis of brahma: the Drosophila homolog of the yeast chromatin remodeling factor SWI2/SNF2.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.