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Article

Molecular changes associated with adaptation of human influenza A virus in embryonated chicken eggs.

Virology - 20 Jun 2006

Widjaja Linda, Ilyushina Natalia, Webster Robert G, Webby Richard J

Abstract excerpt

Failure to isolate A/Fujian/411/2002 (H3N2) in embryonated chicken eggs resulted in its absence from the 2003/2004 vaccine. We analyzed the adaptation of this virus in eggs during serial passages in the amniotic then allantoic cavities. Amniotic passage allowed the virus to grow in the allantoic cavity. During adaptation, 6 amino acid substitutions occurred: 4 in HA (G186V, S219F, V226I, V309I) and 2 in NA...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Viral

Share to Influenza A Virus, H3N2 Subtype

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Source

Identifiers

PMID: 16545416
DOI: 10.1016/j.virol.2006.02.020

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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