Egg fluids and cells of the chorioallantoic membrane of embryonated chicken eggs can select different variants of influenza A (H3N2) viruses.

doi:10.1006/viro.1995.1405

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Article

Egg fluids and cells of the chorioallantoic membrane of embryonated chicken eggs can select different variants of influenza A (H3N2) viruses.

Virology - 1 Aug 1995

Hardy C T, Young S A, Webster R G, Naeve C W, Owens R J

Abstract excerpt

Growth of influenza viruses in embryonated eggs frequently results in the selection of virus variants with amino acid changes near the receptor-binding pocket of the hemagglutinin molecule, yet the mechanism by which this third form of influenza variation occurs (the other two being antigenic drift and shift) has not been clearly defined. Because egg-mediated variation might affect influenza vaccine and...

Topics

Allantois
Amino Acid Sequence
Animals
Cell Line
Chick Embryo
Chickens
Chorion
Dogs
Eggs
Genetic Variation
Hemagglutinin Glycoproteins, Influenza Virus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Hemagglutinins, Viral

Influenza A Virus, H3N2 Subtype

Influenza A virus

Protein Structure, Secondary

Viral Envelope Proteins

Virus Replication

Source

Open in PubMed

Identifiers

PMID: 7645225
DOI: 10.1006/viro.1995.1405

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7645225-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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