Article

Egg-adaptation pathway of human influenza H3N2 virus is contingent on natural evolution

2022-02-01

Abstract excerpt

<h4>ABSTRACT</h4> Egg-adaptive mutations in influenza hemagglutinin (HA) often emerge during the production of egg-based seasonal influenza vaccines, which contribute to the largest share in the global influenza vaccine market. While some egg-adaptive mutations have minimal impact on the HA antigenicity (e.g. G186V), others can alter it (e.g. L194P). Here, we show that the preference of egg-adaptation pathway in...

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Literature Corpus work: d9039d46-d665-5c0b-8477-9dcd19acf5bb
DOI: 10.1101/2022.01.31.478576

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