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Article

Seasonal Influenza Viruses Show Distinct Adaptive Dynamics During Growth in Chicken Eggs.

Molecular biology and evolution - 1 Oct 2025

Kistler Kathryn, Bedford Trevor

Abstract excerpt

Human influenza viruses are grown in chicken eggs for vaccine production. Sequences of these egg-passaged viruses give us the opportunity to examine the evolution that occurs when these human viruses are subjected to the selective pressure of growing in chicken eggs, which (among other things) express different sialic acid receptors. The repetition of this evolutionary experiment in hundreds of strains over the...

Topics

Animals
Chickens
Hemagglutinin Glycoproteins, Influenza Virus
Influenza A Virus, H3N2 Subtype
Mutation
Humans
Influenza A Virus, H1N1 Subtype
Evolution, Molecular
Chick Embryo
Epistasis, Genetic
Influenza B virus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Adaptation, Physiological

Source

Open in PubMed Open full text

Identifiers

PMID: 40974095
DOI: 10.1093/molbev/msaf227
PMCID: PMC12492274

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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