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Sulfated glycans containing NeuAcα2-3Gal facilitate the propagation of human H1N1 influenza A viruses in eggs.

Virology - 1 Oct 2021

Ichimiya Tomomi, Okamatsu Masatoshi, Kinoshita Takaaki, Kobayashi Daiki, Ichii Osamu, Yamamoto Naoki, Sakoda Yoshihiro, Kida Hiroshi, Kawashima Hiroto, Yamamoto Kazuo, Takase-Yoden Sayaka, Nishihara Shoko

Abstract excerpt

When human influenza viruses are isolated and passaged in chicken embryos, variants with amino acid substitutions around the receptor binding site of hemagglutinin (HA) are selected; however, the mechanisms that underlie this phenomenon have yet to be elucidated. Here, we analyzed the receptor structures that contributed to propagation of egg-passaged human H1N1 viruses. The analysis included seasonal and 2009...

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PMID: 34246113
DOI: 10.1016/j.virol.2021.06.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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