Article
Mutational pattern of influenza B viruses adapted to high growth replication in embryonated eggs.
Virus research - 1 May 2005
Lugovtsev Vladimir Y, Vodeiko Galina M, Levandowski Roland A
Abstract excerpt
Improved replication of influenza viruses in embryonated chicken eggs (CE) permits increased vaccine production and availability. We investigated the growth properties of influenza B viruses in relation to specific mutations occurring after serial passage in CE. In serial passage experiments yielding high growth variants of B/Victoria/504/2000, mutations predicted to alter amino acid (AA) composition occurred...
Topics
- Adaptation, Biological
- Amino Acid Substitution
- Animals
- Antigens, Viral
- Chick Embryo
- DNA, Complementary
- DNA, Viral
- Genes, Viral
- Hemagglutinin Glycoproteins, Influenza Virus
- Influenza B virus
- Models, Molecular
- Molecular Sequence Data
- Mutation
- Mutation, Missense
- Nucleoproteins
- RNA, Viral
- Sequence Analysis, DNA
- Virus Replication