Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Egg-adaptive mutations of human influenza H3N2 virus are contingent on natural evolution.

PLoS pathogens - 1 Sept 2022

Liang Weiwen, Tan Timothy J C, Wang Yiquan, Lv Huibin, Sun Yuanxin, Bruzzone Roberto, Mok Chris K P, Wu Nicholas C

Abstract excerpt

Egg-adaptive mutations in influenza hemagglutinin (HA) often emerge during the production of egg-based seasonal influenza vaccines, which contribute to the largest share in the global influenza vaccine market. While some egg-adaptive mutations have minimal impact on the HA antigenicity (e.g. G186V), others can alter it (e.g. L194P). Here, we show that the preference of egg-adaptive mutation in human H3N2 HA is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Influenza A Virus, H3N2 Subtype
Share to Amino Acids

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Chickens

Share to Hemagglutinin Glycoproteins, Influenza Virus

Share to Hemagglutinins

Share to Influenza, Human

Share to Influenza Vaccines

Source

Open in PubMed Open full text

Identifiers

PMID: 36155668
DOI: 10.1371/journal.ppat.1010875
PMCID: PMC9536752

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Egg-adaptive mutations of human influenza H3N2 virus are contingent on natural evolution.PMID 36155668Read ↗

Egg-adaptation pathway of human influenza H3N2 virus is contingent on natural evolutionSemantic proximity Read ↗

Egg-adaptive mutations in H3N2v vaccine virus enhance egg-based production without loss of antigenicity or immunogenicity.Semantic proximity Read ↗

In-depth phylogenetic analysis of the hemagglutinin gene of influenza A(H3N2) viruses circulating during the 2016-2017 season revealed egg-adaptive mutations of vaccine strains.Semantic proximity Read ↗

A structural explanation for the low effectiveness of the seasonal influenza H3N2 vaccineSemantic proximity Read ↗

Epistasis mediates the evolution of the receptor binding mode in recent human H3N2 hemagglutinin.Semantic proximity Read ↗

Identification of human vaccinees that possess antibodies targeting the egg-adapted hemagglutinin receptor binding site of an H1N1 influenza vaccine strainSemantic proximity Read ↗

The emergence of new antigen branches of H9N2 avian influenza virus in China due to antigenic drift on hemagglutinin through antibody escape at immunodominant sitesSemantic proximity Read ↗

The molecular determinants of antigenic drift in a novel avian influenza A (H9N2) variant virusSemantic proximity Read ↗

[Analysis of Egg-adapted Mutations in Influenza A H1N1pdm09 Viruses in Hubei Province of China, 2013-2014].Semantic proximity Read ↗

From Variation of Influenza Viral Proteins to Vaccine Development.Semantic proximity Read ↗

Seasonal influenza viruses show distinct adaptive dynamics during growth in chicken eggsSemantic proximity Read ↗

220 mutation in the hemagglutinin of avian influenza A (H7N9) virus alters antigenicity during vaccine strain development.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.